Published at March 28, 2021 · 3 min read
Background Fundamental Boolean Model (FBM), published in Chen et al. (2018) https://doi.org/10.3389/fphys.2018.01328, provides an intuitive definition of activation and inhibition pathways and includes mechanisms to handle protein decay issues. To prove the concept of the novel model, we implemented an R package, called FBNNet. Our experimental results show that the proposed FBM could explicitly display the internal connections of the mammalian cell cycle between genes separated into the connection types of activation, inhibition and protein decay....